DIRECTIONS FOR USE:
(Enclosed measure approximates 1.5 oz based on density of product.)
Adult Horses (900-1,100 lbs): Provide 1 measure (1.5oz) twice daily for 60 days. For lower maintenance level, provide 1 measure (1.5oz) daily for 120 days or continue as needed
Magnesium (Mg) is a vital macromineral, and it is becoming increasingly recommended by veterinarians for various treatments in the horse. Because one of the clinical signs of magnesium deficiency is nervousness, it is added to many calming supplements. Magnesium helps protect against inflammation and free radical damage. Magnesium may play a role in insulin resistance and equine metabolic syndrome. Within the muscle calcium and magnesium work antagonistically — calcium causing muscle contraction and magnesium inducing relaxation. If there is not enough magnesium, muscles tend to spasm. Although the presence of low magnesium in the muscle tissue may stem from a genetic disorder rather than dietary quantities, there are reports of horses that have responded to magnesium supplementation for treatment of chronic tying-up. Lysine is an amino acid and the only one for which a requirement in the horse has been established by the NRC. It is an essential amino acid, meaning it must be provided in the diet since the body cannot create enough of its own.
Lysine is an amino acid and the only one for which a requirement in the horse has been established by the NRC. It is an essential amino acid, meaning it must be provided in the diet since the body cannot create enough of its own. Lysine is also a limiting amino acid. This means if it is not present in adequate amounts it limits the body's ability to make protein. Lysine is important in the formation of collagen (the protein that forms the matrix of bone, cartilage and connective tissue). Lysine supports normal intestinal absorption of calcium and helps reduce the excretion of calcium in the urine.
Choline is recommended for supporting a healthy nervous system. Choline is a component of acetylcholine, a neurotransmitter. Acetylcholine carries messages between neurons, which enables the brain to communicate with itself and the rest of the body.
Turmeric is a potent antioxidant that helps fight oxidative stress, supports normal inflammatory response and supports overall health.
Cinchona Bark is recognized by scientific research to contain the familiar antimalarial alkaloid quinine that has an impact/support role in the presence of protozoa (parasite type organisms). The medicinally active compounds in cinchona bark are mostly alkaloids.
Ester-C® (calcium ascorbate) is a unique patented ascorbate complex bound with calcium carbonate. Ester- C® is naturally processed in purified water without the use of alcohol or acetone solvents. This makes Ester-C® a more readily available, readily absorbed form of vitamin C. Vitamin C is an antioxidant that helps protect the tissues of the body and also important in the production of connective tissues like tendons and ligamnets. Ester-C® has up to 4X more metabolic activity than standard vitamin C (ascorbic acid).
Grape Seed Extract (GSE) is a very potent antioxidant to help support a healthy immune system. It helps protect against tissue damage from oxidative stress resulting from free radicals generated during equine exercise, immune system activity or environmental exposures.
The Vitamin B family is made up of several compounds that serve many important roles in the body: protein, fat and carbohydrate metabolism; energy production; proper nerve cell transmission; and cell reproduction and division (especially rapidly dividing ones such as red blood cells).B vitamins include thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), folic acid (B9), and cyanocobalamin (B12). For most of the B vitamins, microorganisms in the large intestine make all the horse needs. Only thiamine and riboflavin have NRC dietary requirements. However, research suggests B vitamin supplementation may be beneficial to stabled horses with little access to fresh pasture, heavily exercising horses, pregnant and lactating mares, horses with GI conditions that may interfere with normal gut flora, and any periods of stress (injury, illness, shipping, old age, etc.).
Zinc (Zn) is a micromineral involved in over 100 enzyme systems ranging from support of connective tissue formation and antioxidants
to carbohydrate metabolism and immune system function. It is most recognized for its role in healthy skin
and hooves. Supplementation should be considered because amounts in normal feedstuffs may not meet requirements.
Copper (Cu) is a micromineral required for production of normal connective tissues including tendons, ligaments, cartilage and bone. As a component of many enzyme systems, it is also involved in making iron available to the body for blood, in producing skin and coat pigments, in proper nerve signaling and in repairing antioxidants. Low copper levels in mares and foals have been implicated in developmental orthopedic disease (DOD) including osteochondrosis (OCD).
Selenium is a trace mineral that along with vitamin E function in a partnership that helps to protect body tissues from free radical damage that occurs during oxidation (the conversion of feedstuffs into energy). In particular, they act as a defense mechanism against damage to cell membranes and enzymes. While some parts of the country have high levels of selenium in their soil and therefore, the plants that grow there, selenium deficiency has been reported in 46 states. Therefore, most horses will need supplementation to meet the NRC requirement of 1 mg/day for maintenance. For optimum immune function and exercise recovery, 2 to 3 mg/day is recommended, which is still well below 50 mg/day which may be the upper safe limit. Selenium yeast, the organic form of the mineral, is better absorbed than inorganic selenium selenate or selenite.
Vitamin E is considered the most important antioxidant and works closely with selenium to protect the body from the oxidative stress of exercise, illness and certain medical conditions. Found in high amounts in fresh pasture, levels begin to decay the moment pasture is cut for hay. That is why any horse that does not have access to grass, regardless of its activity level or health, should receive vitamin E supplementation. Horses are not very efficient in storing vitamin E and deficiency may be accelerated if the diet is deficient in selenium. Synthetic vitamin E is bioavailable but studies show that it is 21 ⁄2 times more bioavailable than synthetics.
Active Dry Yeast: Supports enzyme activity for fiber digestion in the hind gut and provides a direct source of nutrients to nourish good bacteria. Stabilizes digestive flora during periods of stress for overall health and performance.
Probiotics are live microorganisms fed to promote healthy digestive and immune function. When these "good" bugs break down food ingredients that the body normally cannot, they produce energy and vitamins for the body, food for cells in the cecum and colon, and byproducts that keep the "bad" bugs from growing. Research suggests probiotics are useful in repopulating the intestine with "good" bugs after antibiotic use and may benefit certain horses with diarrhea. A common term used for probiotics is direct-fed microbials (DFM).
Can my horse stay on E-Clipse'PM indefinitely or only 120 days?
MVP: It is recommended to feed the E-Clipse'PM at the rate of 1 scoop both AM & PM for the first 60 days. Thereafter, you may reduce to 1 scoop daily for 60 days or as needed for immune support. So yes, it is fine to feed indefinitely to provide immune support. Note: Important to keep immune system boosted for horses who have been treated for EPM to help decrease the risk of relapse. Natural E 5,000 is another good choice as a maintenance immune support supplement.
I just opened my E-Clipse'PM and it has a strong odor, is this normal?
MVP: Due to the high levels of the active ingredients in E-Clipse'PM it does have a slightly stronger aroma, especially when first opened. After a few days of being opened, the scent will fade a bit. Most horses eat it readily but if you are concerned we recommend leaving the bag open for a few days before feeding and then gradually introduce in to diet starting with a ½ serving working up to the full serving over the course of 3-4 days.